Andy Serkis's directorial debut to premiere at Toronto Film Festival

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Of the 45 films announced, at least a dozen are directed by women.

Jolie's First They Killed My Father is set to hit the festival, a few months after the passion project about the Khmer Rouge genocide premiered in Siem Reap, Cambodia.

Other films on the docket include Darren Aronofsky's psychological thriller "Mother!" starring Jennifer Lawrence, and "I, Tonya", starring Margot Robbie as ice skater Tonya Harding.

In recent years competition has heated up between Toronto and rival events in Telluride, Colo., and Venice, with all three vying to land world premieres of coveted films.

On Tuesday, organizers revealed just under a quarter of the slate of films set to screen at the annual celebration of cinema, which runs from September 7 to 17. The documentary "Long Time Running" profiles Canadian rock outfit Tragically Hip.

George Clooney's latest, Suburbicon, finds him teaming with longtime collaborators Joel and Ethan Coen, who penned the movie's script.

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"It's a moment of incredible transformation, disruption, change, challenge, so I think you'll see that reflected in the films we're showing", said Piers Handling, chief executive and director of the film festival, now in its 42nd year. Joe Wright's new Winston Churchill biopic, Darkest Hour, stars Gary Oldman as the British Prime Minister in the early years of World War II, while Steve Carell and Emma Stone's upcoming film, Battle of the Sexes, recreates the legendary 1973 tennis match between Billie Jean King and Bobby Riggs.

Other highlights will be "Mary Shelley" by Saudi Arabia's first female director Haifaa Al Mansour, which stars Elle Fanning as the English author of the Gothic horror tale "Frankenstein", and Dee Rees' "Mudbound", a story of racial tensions in the segregated American South.

"The sporting life also takes centre stage at TIFF this year, as Steve Carell meets his match with (honourary Canadian) Emma Stone in Battle of the Sexes; Margot Robbie chases Olympic gold in I, Tonya; Paul Rudd goes from Major League Baseball to OSS in The Catcher was a Spy; and Jake Gyllenhaal and Tatiana Maslany navigate the aftermath of the Boston Marathon bombing in David Gordon Green's Stronger".

The festival runs until September 17.

- Scott Cooper's period drama "Hostiles", starring Christian Bale, Rosamund Pike, Adam Beach and Ben Foster.

Hany Abu-Assad's "The Mountain Between Us", starring Idris Elba and Kate Winslet, is about two strangers stranded on a mountain after surviving a plane crash.