National sides across Europe will compete in the new league format that will culminate in a Final Four showpiece event in 2019 for the title of Nations League champion.
The Nations League - the brainchild of Michel Platini - is being introduced to bring in more interest in friendly dates while there is the added bonus of a backdoor entry into Euro 2020.
Joining England in the top division are France, Germany, Spain, Portugal, Belgium, Switzerland, Italy, Poland, Iceland, Croatia and the Netherlands.
Uefa has confirmed the line-up of each of the four leagues that make up the inaugural Nations League, the European competition created to replace most worldwide friendlies.
However, the Nations League will be used to decide the seedings for the Euro 2020 qualifiers and, on top of that, offer four non-qualifying teams a "back door" route into Euro 2020.
Euro 2020 qualifying will then take place between March and November 2019, with the Uefa Nations League Finals for the top four teams in June 2019.
Ireland will be joined by Wales, Austria, Slovakia, Russia, Sweden, Ukraine, Bosnia, Northern Ireland, Demark, Turkey and the Czech Republic.
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The League Phase Draw for the UEFA Nations League will take place in Lausanne on 24 January 2018.
Each of the four leagues A, B, C and D will contain four groups of three or four teams, with these decided in a draw on next January.
The other 43 European nations will be spread across three other Leagues B, C and D - the group winners will be promoted to replace the nations finishing bottom of Leagues A, B and C for the next Nations League which begins in September 2020.
Teams will be drawn into four groups of four.
In a similar format, the four group winners will advance to the semi-finals.
And League D consists of Azerbaijan, FYR Macedonia, Belarus, Georgia, Armenia, Latvia, Faroe Islands, Luxembourg, Kazakhstan, Moldova, Liechtenstein, Malta, Andorra, Kosovo, San Marino and Gibraltar.
UEFA's website has a full breakdown of how the Nations League will work.
The Euro 2020 qualification play-offs are set for March 2020 as mentioned above, and Euro 2020 itself, which will be played across the continent, will begin three months later.