Crystal Palace are the first side in England's top four divisions to lose their first six games of the season without scoring.
Timothy Fosu-Mensah is on loan at Selhurst Park from Saturday's opponents and as such is ineligible to play.
Chelsea now has 13 points, and they won't like to drop any more points, especially by losing against the title contenders club.
For Palace, with seven straight defeats and no goals, rooted to the bottom of the table, things look ominous.
With 80 shot attempts in six matches, the Eagles rank ninth in the Premier League. And they have not scored a single goal yet.
United's defence has been solid so far this season and would be hoping to keep the Eagles attackers at bay. But, having made five changes from that game, they did not look exhausted at all.
Indeed, the Portuguese manager will be without as many as seven first-team players ahead of the visit of Roy Hodgson's men on Saturday.
What to expect in the match?
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United has dropped two points this campaign so far.
MUTV's Paddy Crerand: "It was another terrific display by United". So, Man. United will be the victor of this match (3-0) as our prediction. United's wunderkinds Rashford and Martial are at the top of their form right now.
The Red Devils have never lost a Premier League game to Palace.
Manchester United have been simply unstoppable at home.
However, according to Oliver Kay of the Times, this performance may not have been enough to earn Martial a start against Crystal Palace on the weekend.
However, Crystal Palace is a strong side, judging by the players at the club's disposal.
United is favorite to win the game.
"We have a double-fixture against Benfica, who have zero points". Juan Mata opened the scoring inside three minutes and Marouane Fellaini netted either side of halftime. Jose can bring the Spaniard midfielder Herrera to replace the Belgian. He is a fighter, a guy with lots of pride and I am really pleased I helped him reach this level and change the perception the fans have now.