The 28-year old batsman who is nicknamed Killer Miller was dropped on zero in South Africa's 100th T20 global took just 35 balls to score his remarkable T20I century which became the fastest ever in the shortest format of the game.
Bangladesh were in trouble early in their reply and never recovered as they were bowled out for 141 in 18.3 overs.
While South Africa gained valuable preparation under new coach Ottis Gibson ahead of tours by India and Australia, Bangladesh failed to live up to the promise it showed recently in home series.
Miller hit nine sixes including five consecutive in an over of Saifuddin, and seven fours in his innings.
The result sees South Africa wrap up a 2-0 victory in the T20I series and a comprehensive whitewash of the tourists.
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Bangladesh came closest to something to celebrate when it went down by 20 runs in the first T20.
"It's a really special feeling", Miller told SuperSport.
The left-hander came to the crease at the fall of the third wicket with the score at 73-3, and made the visitors pay after Mushfiqur Rahim dropped him on nought off Rubel Hossain's bowling.
Cricketers to score a T20I century at a position lower than No. 4 - Miller is the first one to do so. This was a special innings as in getting a century in 35 balls in the course of the 36-ball knock, Miller created an worldwide T20 record. The famous record was previously held by his counterpart Richard Levi, who smashed his century in just 45 balls against the Kiwis in 2012.
Needing more than 11 an over from the start, Bangladesh didn't have the firepower to threaten the Proteas, a story that played out through most of the tour.