The first-choice trio of Laurent Koscielny, Nacho Monreal and Sead Kolasinac remain injured ahead of Wednesday's trip to Stamford Bridge with none of the three to have featured this year.
The midfielder will have everything crossed as he has the knock looked over by the Arsenal medical staff, having only recently looked to have reignited his Arsenal career this season.
The England worldwide has endured a career riddled with injury spells - with his first coming as a 17-year-old in 2009 - having fractured his ankle in 2011 followed by numerous setbacks which included more ankle damages as well as a broken fibula in 2015 pre-season.
GoPro exits drone market and slashes jobs amid sales warning
Near 2010 GMT, shares of GoPro were down 13.5 percent at $6.52 after falling as low as $5.04 earlier in the session . For now, the company appears to be doubling down on the one thing it does know how to do: make small action cameras.
Wilshere went down after blocking a cross from Victor Moses and tried to shake the injury off in the next couple of minutes.
The best chance of a largely uneventful first half came right on the stroke of half time, though, as Fabregas latched on to Cesar Azpilicueta's trademark cross from deep only to plant his header straight at Ospina.
The first saw the Spaniard turn into space before quickly releasing a 25-yard effort which Ospina needed to parry away, before Morata then rolled Shkodran Mustafi to race through on goal and squeeze his finish under the onrushing Arsenal keeper, only to see it trickle into the side-netting.
The two London sides played out a thrilling 2-2 draw when they met in the Premier League at The Emirates last week.
Chelsea, meanwhile, are also aiming to bounce back after their goalless draw with Norwich in the third round on Saturday.