Ibuprofen may increase risk of fertility issues in men, study suggests

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Those who took the ibuprofen were more likely to have indications of testicular problems - including a condition called compensated hypogonadism that affects reproductive health - meaning men are less likely to be able to father a child. LH's job is to stimulate the production of testosterone, so higher levels of LH without corresponding higher levels of testosterone could suggest an issue in the way the body's hormones are functioning. While the testosterone levels in the men taking ibuprofen had not changed, researchers found their pituitary glands were boosting testosterone production anyway, inducing the compensated hypogonadism.

The study involved 31 men, 14 of which were given a daily dose of 600 milligrams ibuprofen twice a day - the amount commonly consumed by athletes, CBS News reported. Until now, it has been primarily linked to adverse effects such as gastrointestinal bleeding, cardiovascular disorders and kidney damage. A new study says the well-known painkiller could cause fertility issues in males.

As it relieves pain, ibuprofen may also diminish male fertility, according to a small but compelling new study. Each dose was 600mg, equivalent to three over-the-counter pills.

Previous research by the team, which focused on pregnant women, had found that the use of Paracetamol and Ibuprofen during pregnancy affected the testicles of male babies. Luckily, in the test subjects the condition was mild, but the researchers said people should be concerned if they use anti-inflammatory drugs regularly over long periods of time.

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HollywoodLifers, did you know the negative effects of ibuprofen? "The risk is greater than the benefit". The researchers measured the level of LH in the bloodstream of the test subjects who were taking Ibuprofen and found it to be significantly higher than in test subjects not taking the drug. "Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial..." the study states.

"These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines", he added.

While "it is sure" that the hormonal effects in the study participants who used ibuprofen for only a short time are reversible, it's unknown whether this is true after long-term ibuprofen use, study co-author Bernard Jegou, director of the Institute of Research in Environmental and Occupational Health in France, told CNN.

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