Now in its 24th year, Vanity Fair's annual Hollywood issue has become a significant feature of awards season, bringing together several of the stars likely to be in the running at that year's Academy Awards. Focusing on the cover, many initially thought Witherspoon had three legs.
Naturally, the errors have become the subject of much ridicule on Twitter.
However, the two stars laughed off the confusion on Twitter, with Witherspoon joking that she hopes fans "can still accept me for who I am" after the revelation of her third leg. "As I know you accept my 3d hand".
Lead image by David Torcivia used under Creative Commons. Oprah is seen with one hand on her waist, one hand on her lap - and another hand around Reese's waist. "Well ... I guess everybody knows now ..."
Even Oprah and Reese have hilariously tweeted about the spot.
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Another woman, Sarah Tither Kaplan, claims Franco was filming an orgy scene when he removed the protective coverings the women had over their genitals and did not stop simulating oral sex.
He's also taken exception with the allegations reported in a Los Angeles Times exposé, which included five women accusing Franco "of behavior they found to be inappropriate or sexually exploitative".
All thanks to digital scrubbing of James Franco from the cover Vanity Fair Hollywood Issue.
Franco's disappearance was not the only aspect of the Vanity Fair cover to set tongues wagging.
Golden Globe victor and SAG Award nominee, actor James Franco who was accused of sexual misconduct has been removed from Vanity Fair's newly released Hollywood Issue cover amid the allegations made against him.
Reese Witherspoon and Oprah Winfrey just got some extra pair of limbs.
He explained, "I pride myself on taking responsibility for things that I've done. It's, I think, a good thing, and I support it".