The Saints came into this clash unbeaten in six games and looking for their first back-to-back league wins since April a year ago, but were undone by the quality of Liverpool's front-line and now remain winless at St Mary's since November 26.
Much like Klopp's attack-minded side, Porto play a high press and transfer from defence to attack with the use of their speedy wingers.
The winter transfer window saw van Dijk become the world's most expensive defender, costing the Reds a cool £75m to take him to Merseyside, and his start to life at Anfield hasn't exactly been flawless.
Meanwhile, Liverpool have announced that Nathaniel Clyne has returned to full training after overcoming a back injury, but is some way off from being available for selection.
Yesterday the Kop boss bumped into Iker Casillas in a hotel lobby.
Spanish keeper Casillas, now aged 36, has been relegated as a substitute for Porto and is expected to once again be overlooked at the Estadio do Dragao.
The 26-year-old has missed 37 matches this season due to a back injury. The first challenge is to get into the last eight.
Sergio Conceicao's Porto side sit at the top of the Primeira Liga table, two points above Benfica, with a game in hand.
Eurostar To Start Offering Direct Trips Between London And Amsterdam
The new service travels from St Pancras International to Amsterdam Centraal station, with a journey time of three to four hours. Stay on the train for another hour and 13 and you're in Rotterdam, and Amsterdam is only another 40 minutes from there.
"I think both teams will fancy their chances of going through", he added.
It was no surprise to me that Saints improved defensively when he went because he had become a waste of space. It makes no sense.
"I don't like talking about the round after the round you are playing, in fact I hate it". Only because I am a friendly person I answered the question, because we are in public.
"Last summer we dreamt of it and now we are here". I feel good, I feel strong.
"Nobody wants to play against Porto". They are a mixture of football and fight. Nine league titles in 11 seasons at the turn of the century made them an attractive proposition for those looking to adapt to football on the continent, while the club thrived without the pressure of expectation on the European stage. It's quite a job to do.
"Systems are very important but only to bring players in their best positions". They can win one-off games.
"It's about the players and their decision making and doing the right thing in the right moment".
"They do some sensational stuff in training, but you've seen the best of them out on the pitch".
Porto and Liverpool face each other Wednesday.