With United reeling, Ben Yedder soon added his eighth goal of this season's Champions League, De Gea unable to claw out the striker's looping header.
United, three time winners of this competition, drew 0-0 in the first leg in Spain last month.
The problem now is that he is still inflicting misery on United - ask the supporters what they think of his approach to the game - but should he really be doing that as the team's manager?
His negative tactics were ultimately undone by Sevilla coach Vincenzo Montella, whose second-half tactical switch, introducing substitute Ben Yedder for Luis Muriel, prove the decisive moment in the game.
Though the Italians lost the first leg 2-1, they progressed through on the away goals' rule.
"I sit in this chair twice in the Champions League and knocked United out of the Champions League, with Real or Porto, so I don't think it is something new for the club".
"We'll be playing 100 per cent to try and achieve that".
Woodburn students to join national walkout
However, the law empowers schools to establish limitations to maintain order and minimize disruption to the school day. Hoffman said students would leave class on March 14 and march on Broadway to Chelsea City Hall for a gathering.
In the 74th minute, Ben Yedder broke the deadlock just two minutes after coming off the bench.
Neither Real Madrid nor Barcelona sidelined their attacking players to stifle N'Zonzi when facing Sevilla but Fellaini's selection was purely a result of the presence of the former Blackburn and Stoke player. We had unsafe situations in the first half, a good start in the second half and chances to score.
Hello good evening and a warm welcome to another night of UEFA Champions League football.
Minutes later it was Sevilla's turn to breathe a sigh of relief, as Lukaku turned provider for Lingard this time, but the outstretched hand of Sergi Rico tipped the Englishman's shot around the post for a corner that would ultimately come to nothing.
Ivan Ordets was sent off with 10 minutes to go for Shakhtar for a foul on Dzeko who was running through, making his team's bid for a goal to send them through harder.
"But I believed in myself, believed in the team and we showed we are a great team".
But it was to little avail as United have now failed to reach the quarter-finals for four straight years.