It comes just over a month before the first anniversary of the Islamist terror attack during Grande's concert a year ago, in which 22 people died and more than 500 were injured.
The concert raised about £3m for the We Love Manchester Emergency Fund.
Time to get excited Arianators - Ariana Grande has officially confirmed details of her new single, called No Tears Left To Cry. It's the only news that could have possibly rescued us from the mid-April blues, and we're shrieking at the top of our lungs. A revamp usually happens just before a new era is ushered in.
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Video director Dave Meyers, who shot Camila Cabello's Havana and Kendrick Lamar's Humble, also posted the phrase "no tears left to cry" on his Instagram account on Tuesday, suggesting he had worked on the star's comeback.
Hard dance moves, sexy outfits, catchy songs. She also confirmed the song and release date.
It was actually Ariana's mother Joan who first teamed the news, almost 24 hours before Ari herself did anything.
The 24 year old memorably became Manchester's first honorary citizen in the aftermath of her response to the bombing, when she headlined and helped to organise the One Love Manchester concert just two weeks after the atrocity.