Weinstein is free on one million dollars cash bail.
His lawyer, Benjamin Brafman, has challenged the credibility of the alleged victims. "Mr Weinstein intends to enter a plea of not guilty and vigorously defend against these unsupported allegations that he strongly denies".
They said the former movie mogul did not have enough time to prepare to testify, and that he only learned on the day he was charged of the identities of the two women relating to the charges.
The 66-year-old producer, whose career imploded in a blaze of accusations of sexual misconduct and abuse from dozens of women that triggered a global reckoning about harassment in the workplace, could face up to 25 years in prison if convicted.
The Associated Press does not identify alleged victims of sexual assaults unless they come forward publicly.
Brafman says he wants to separate the charges against Weinstein and have separate trials, because the alleged incidents happened eight to 10 years apart.
The other accuser, former actress Lucia Evans, who has waived her right to anonymity, alleges that Weinstein forced her to perform oral sex at his office in 2004.
Guatemala's Fuego volcano claims lives in deadly eruption today
She said: "Not everyone escaped, I think they were buried". "Evacuations and searches are under way", he said, quoted by Reuters . Eddy Sanchez, director of the country's seismology and volcanology institute, said the flows reached temperatures of about 700C.
He said Spiro - who resigned from Brafman & Associates in September but still had access to his company email - met with the woman only after leaving the law firm.
Shortly before Weinstein arrived, celebrity lawyer Gloria Allred strode into court, showing the signature determination that famous men accused of sexual misconduct have come to recognise all too well.
"Mr Weinstein is presumed innocent. however reprehensible the crime may be, it is also reprehensible to falsely accuse someone of rape", Brafman said. Brafman then offered several hints of his pretrial strategy to the judge and lead prosecutor Joan Illuzzi.
Manhattan District Attorney Cyrus R. Vance Jr. has said it was predictable that Weinstein's camp would attack the integrity of the women and the legal system.
"I said, over and over, 'I don't want to do this, stop, don't, '" Evans told The New Yorker in a story published in October.