Clooney said a auto turned in front of him and he hit it head-on, smashing the windshield, CNN reported.
It's thought he has sustained a hip injury from the incident and has since been released from hospital.
Clooney was driving when a vehicle suddenly pulled in front of his motorbike.
A picture from La Nuova shows a smashed windscreen, which suggests George hit it during the crash, but despite this, his condition is not thought to be serious.
Clooney's spokesman, Stan Rosenfield, explained the accident to the media, relaying that, "He's doing fine".
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In the hospital, he was joined by his wife Amal and they left the venue together in a private vehicle.
It is reported that George was then x-rayed and seen to by a doctor, before being discharged the same morning and leaving the premises in a chauffeur driven vehicle.
Clooney was in Sardinia shooting his Hulu limited series Catch-22. She recently paid her very first visit to Toronto alongside her father-in-law, journalist Nick Clooney.