The 2015 agreement curbed Iran's nuclear program in return for lifting most worldwide sanctions.
"I'm ready to meet anytime they want to", Trump said of Iran during a joint press conference with Italian Prime Minister Giuseppe Conte on Monday.
Pompeo said it would require "enormous change" by Iran to get out from under renewed us sanctions.
The sanctions, which will target Iran's central bank and make it hard for the country to conduct worldwide business, including the exportation of oil and minerals, were lifted when Tehran signed the global nuclear deal in 2015 and agreed to dismantle most of its nuclear production facilities. "I will meet, or not meet, it doesn't matter - it is up to them!"
Nephew highlighted the automotive sanctions as one of the more significant in the group since Iran had ambitions for auto exports to become a bigger part of its economy.
Trump's offer of talks came only days after he cautioned Iran in a tweet responding to President Hassan Rouhani's earlier vitriolic comment effectively threatening Washington and said, "You will suffer consequences the likes of which few throughout history have ever suffered before".
This past week, though, Trump said he'd be willing to meet with Iranian leaders without any preconditions.
Iran's Foreign Minister Mohammad Javad Zarif at a bilateral meeting with China's Foreign Minister Wang Yi on the sidelines of the ASEAN Foreign Ministers' Meeting in Singapore, August 2018.
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Iran experts are skeptical Trump could repeat that formula with Rouhani.
"China always holds the view that JCPOA is a multilateral deal which is verified and approved by the United Nations Security Council and accords the common interests of all parties and the global community, which must be respected and safeguarded so as to maintain the authority of the United Nations, the effectiveness of multilateral deals and the credibility of the worldwide rules", Yi reportedly said.
If the re-imposed sanctions caused the government in Tehran to collapse, Iran would likely devolve into civil war like what unfolded in Syria or radicals would assume power, the diplomat said.
Coffey, at Heritage, said the approach to Iran has to be "completely different" from North Korea.
"Iran, and it's economy, is going very bad, and fast!"
The UK, along with China, Germany, France, Russia and the European Union are negotiating with Iran on preserving the deal.
Coffey said he believes Trump's withdrawal from the Iran deal was an "opening gambit" for a new deal.
ANKARA, Aug 5 (Reuters) - Iran will ease foreign exchange rules, state TV reported on Sunday, in a bid to halt a collapse of the rial currency that has lost half its value since April due to fears about US sanctions likely to be imposed this week.