The Kavanaugh nomination has turned into a political firestorm ahead of November congressional elections - in which Republicans will battle to keep control of Congress - and is threatening to derail Trump's push to get a conservative-minded majority on the top court ahead of the vote.
"But when individuals provide fabricated allegations to the Committee, diverting Committee resources during time-sensitive investigations, it materially impedes our work", he said.
Flake was persuaded as he watched Coons renew his call for an FBI investigation.
Ana Maria Archila and Maria Gallagher stopped Flake on Friday morning and spent almost five minutes shouting at the Arizona lawmaker after they learned he had made a decision to support the US Supreme Court nomination of Judge Brett Kavanaugh.
West Virginia Democrat Joe Manchin said he supported Flake's call for a further probe "so that our country can have confidence in the outcome of this vote".
White House spokesman Raj Shah said the Senate set the scope and duration of the investigation and that the White House is "letting the FBI agents do what they are trained to do".
In an interview published Saturday in The Atlantic, Flake said his refusal to issue a vote on Kavanaugh without a week-long "pause" for an FBI investigation into the allegations of sexual misconduct against Kavanaugh was a last-ditch effort to overcome partisan battles that have plagued the confirmation process.
A committee spokesman on Saturday declined to elaborate beyond the statement.
The FBI is also being restricted from investigating Kavanaugh's account of his own drinking habits, according to NBC News.
PFAW Response to Trump Press Briefing on Kavanaugh Allegations
Trump also applauded his work in North Korea and highlighted his positive relationship with dictator Kim Jong Un. "This is America we're talking about".
Sen. Jeff Flake of Arizona crystalized the challenge before the GOP. The FBI's interviews, which will take a few days to conduct, won't turn into a sprawling inquest of everyone Kavanaugh went to a party with in high school, said a person familiar with the investigation.
Lawyers for PJ Smyth and Leland Ingham Keyser, two others who Ford said were in the house when she was attacked, have said their clients are willing to cooperate "fully" with the FBI's investigation. He has been accused of sexually assaulting Christine Blasey Ford, a professor of psychology in California, in 1980s.
"Ms. Keyser does not refute Dr. Ford's account, and she has already told the press that she believes Dr. Ford's account", Keyser's attorney, Howard Walsh, wrote in the letter, which was sent to the committee overnight Friday. "However, the simple and unchangeable truth is that she is unable to corroborate it because she has no recollection of the incident in question".
The FBI is also investigating the allegation of Christine Blasey Ford that Kavanaugh sexually assaulted her when they were high schoolers in the Washington, DC, suburbs.
"Laughter - the uproarious laughter between the two", Ford, her voice wavering, told the Senate Judiciary Committee at Thursday's extraordinary hearing.
Two other key Republicans, Susan Collins of ME and Lisa Murkowski of Alaska, said they backed the plan after they and other GOP senators met for an hour in Senate Majority Leader Mitch McConnell's office in the Capitol. "His face was white and very uncomfortable saying "hello" back".
Hours earlier, Ford spoke at the public hearing.
Senate Judiciary Committee advances Brett Kavanaugh's Supreme Court nomination in party-line vote, as Sen. She hasn't accused Kavanaugh of raping her. Swetnik described Kavanaugh as a "mean drunk" in high school who was physically and verbally aggressive with girls.
Kavanugh has denied the accusations by Ramirez and Swetnik and has said emphatically that he never abused or assaulted anyone.