Marcus Rashford got ahead of Alexander-Arnold with the eye on goal, but flashed his effort way off target on 26 minutes.
Eric Dier, Ruben Loftus-Cheek and Fabian Delph will start in midfield, while Danny Welbeck joins Rashford up front.
Manchester United defender Luke Shaw could play in Saturday's Premier League game at Watford, a week after suffering concussion while playing for England. Over at Old Trafford, however, he has only managed three goals since March.
But after scoring in Saturday's 2-1 defeat to Spain and the victor against Switzerland on Tuesday, he can be assured he will stay in Southgate's squad for the time being.
"We had a tactical problem to sort out and so many lads playing their first 45 minutes of the season", he added of the first-half display. "We are hoping that now we have given them some minutes they will go back to their club better prepared for when they get their opportunity and it gives them a better chance of staying in the team. But we can see there's a period of time for those players to come through". "A real breakthrough for him".
Zach Daniel provides update on potential Hurricane Florence impact in Virginia
As of noon EDT, Florence was centered about 575 miles (925 kilometers) south-southeast of Bermuda, moving west at 13 mph (20 kph). The hurricane center projects that Helene will strengthen Monday but "weakening is forecast to commence Wednesday morning".
"We are going to have to assess that each time".
To make a tough job even harder for the 18-year-old, this summer he saw Guardiola spend a club record £60m on Riyad Mahrez.
'I still have to be fit, strong, train well and play well.
Rashford aside, Danny Rose also caught the eye on England's left flank before giving way to local favourite Ben Chilwell, who made his worldwide debut.
"His first season was last season and he had a fantastic season, he got the player of the year award and he rightly deserved that as well".
The game was also a reminder of just how unbearable the England band are.