Clearly Djokovic will have to neutralize the 6'6" Argentine's blistering serve at the Arthur Ashe Stadium: "Del Potro fired 68 aces during the tournament, winning 82 percent of his first serve points.
For Del Potro it wasn't to be, but his return to a Grand Slam final nine years after his first with four wrist surgeries in between deserves vast credit.
He is now set to rise to third in the ATP rankings behind Rafael Nadal and Roger Federer, the only two men to have claimed more slam titles, but can justifiably claim to be the best player in the world at present.
Del Potro was looking at having to become the first man since Pancho Gonales in 1949 to win the United States title from two sets down.
"When I had my surgery I could truly understand what Juan Martin was going through when he had surgeries that kept him away from the tour for two or three years", added Djokovic.
"Del Porto, who turns 30 later this month, might have reached the final unexpectedly, but the 6'6" Argentine's blistering serve is something that could bring trouble for Djokovic.
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Djokovic began the second set in the same vein applying huge pressure on Del Potro's serve.
"There was always part of me that believed I could come back relatively quickly to the level of tennis that I once was playing", Djokovic, 31, said before Sunday's match.
Djokovic was soon 3-1 up in the second set before Del Potro carved out his first break point of the match to level at 3-3.
From 40-0 down, Djokovic broke down his opponent with careful and precise ball striking, teasing the error out of the tentative Del Potro.
Asked who he dedicated the win to, Djokovic - who has won his last 13 matches after beating rival Roger Federer in the Cincinnati Masters last month - said: "To the support of the loved ones, my kids, my wife, my team of people, a small team of people that have been there with me through hard times as well".
In a tight opening set, there was only a single break point and Djokovic made it count to go up 5-3 before serving it out. But Djokovic was in no mood to hang around, winning the last three games to clinch the crown.
"Of course I'm sad I (lost)", del Potro said.