George and Amal Clooney became close friends with Harry and Meghan after the former actress relocated to London.
"We've seen how that ends", Clooney added in reference to Princess Diana's fatal auto crash in 1997, which occurred when the vehicle was being chased by paparazzi.
Clooney, who attended Meghan and Harry's wedding previous year alongside his wife, human rights lawyer Amal Clooney, said he had seen the recent coverage about the Duchess's supposed letter.
And George - who has 18-month-old twins Ella and Alexander with wife Amal - also claimed it was "irresponsible" when Meghan's father, Thomas Markle, made public a letter the duchess had sent to him last summer. "She's getting a raw deal there".
Ariana Grande, A No-Show, Wins First Ever Grammy Award
The 61st Annual Grammy Awards are broadcasting live from Staples Center in Los Angeles on Sunday, Feb. 10 at 8:00 p.m. Grande blasted the comments in a social media post , saying she could have prepared a performance overnight.
Harry and his elder brother Prince William, the second in line to the throne, have had a strained relationship with the press since their mother, Princess Diana, was killed in a auto crash in Paris in 1997 while being chased by paparazzi on motorbikes.
It's just another blow for the pair's severely fractured relationship, which has been in tatters since Thomas pulled out of her wedding just days before it was due to take place, after he was reportedly admitted to hospital for heart surgery. His reason to continue to speak up, he argued, is because "Meghan and Harry's silence empowers all the insane tweets and insults against me and my family".
Meghan was wearing Ralph Lauren in the photo and as Violet was working for the designer, she told Harry that the Hollywood star was in the country.
While penning an open letter for British magazine Hello, The Duchess of York has revealed just how similar the media's portrayal of a feud is to what she experienced with Princess Diana. On a daily basis you fixated and clicked on the lies they were writing about me, especially manufactured by your other daughter, who I barely know.