Bills 2019 schedule release officially set for Wednesday, April 17

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That date means the game will be played in Week 9 of the '19 season. The first such game happened in 2016 in Mexico City against the Oakland Raiders.

The Bears have previously played two games in London, both at Wembley Stadium. A fifth global game will be played in Mexico City between the Chiefs and Chargers.

Six games: The Vikings will play the usual home-and-away series with their NFC North rivals, the Bears, Lions and Packers.

The schedule will also include four trips (Baltimore, Cincinnati, Tampa Bay, Washington) to the Eastern time zone, where San Francisco has not won a game since the 2014 season (at New York Giants on November 16, 2014).

The NFL will play two games at Tottenham Hotspur Stadium and two at Wembley Stadium in 2019.

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The NFL will release the regular-season schedule Wednesday at 8 p.m., but the overseas trip nearly certainly means Carolina will follow its Week 6 game in London with a bye week in Week 7.

The Carolina-Tampa Bay matchup is the second contest in this year's worldwide series.

The Buccaneers-Panthers contest will be just the second NFL game played at Tottenham Hotspur Stadium, a multi-purpose facility constructed specifically to host soccer and American football contests, as well as other events.

The Los Angeles Rams and Kansas City Chiefs were originally scheduled for a game at Estadio Azteca previous year, but poor field conditions forced the game to be relocated to L.A.