The Supreme Court suspended her death sentence in October in a judgment hailed by rights groups.
"Fantastic news that Asia Bibi appears to have left Pakistan safely", he tweeted, adding that he was about to meet U.S. Secretary of State Mike Pompeo "to talk about persecution of Christians around the world". The Supreme Court's quashing of her sentence on October 31 previous year led to violent protests by religious hardliners who support strong blasphemy laws, while more liberal sections of society urged her release. The letter condemned the country's blasphemy laws and said that the signers would be "compelled to call on the European Commission to suspend all subsidies and trade preferences until the effective implementation of the Convention could be assured by the Government of Pakistan". "Her children are in Ottawa and she has been reunited with them".
The Pakistan government had in November rejected reports claiming Asia Bibi has fled abroad, saying the images on the social media showing the recently-acquitted Christian woman being greeted overseas are "fake". She received her passport last Wednesday, he said. "Aasia Bibi has left the country".
"Bibi has been reunited with her family in Canada, " Shamoon Gill, a Christian activist from All Pakistan Minorities Alliance, said.
The White House and the American Center for Law and Justice, which fought for Bibi's freedom for more than four years, have declined to comment regarding Bibi's asylum appeal.
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It is an incendiary issue in the Muslim-majority country, and mere allegations of insulting Islam have sparked lynchings and vigilante violence in the past.
He said she was longing to see her daughters, with whom she talked to nearly daily from her secure location, protected by Pakistani security forces.
The case has brought worldwide attention to Pakistan's controversial blasphemy law, which carries an automatic death penalty. The assassin, Mumtaz Qadri, has been celebrated as a martyr by hard-liners since he was hanged for the killing, with millions visiting a shrine set up for him near Islamabad.
Ms Bibi, a farm worker and mother, was convicted in 2010 of making derogatory remarks about Islam after neighbours working in the fields with her objected to her drinking water from their glass because she was not Muslim.
Pakistan's Supreme Court upheld the verdict in January. No executions for blasphemy have been carried out in Pakistan but enraged mobs sometimes kill people accused of blasphemy.
According to the BBC, Christians make up only 1.6% of the population.